Acute postoperative pain following total knee arthroplasty

Acute postoperative pain following total knee arthroplasty refers to moderate-to-severe nociceptive and neuropathic discomfort arising immediately after surgical reconstruction of the knee joint Pathophysiologically, the pain stems from extensive tissue trauma, including bone resection, periosteal disruption, capsular distension, and soft-tissue injury, which incite local inflammation, peripheral nociceptor sensitization, and heightened central nervous system responsiveness

Acute postoperative pain following total knee arthroplasty refers to moderate-to-severe nociceptive and neuropathic discomfort arising immediately after surgical reconstruction of the knee joint

It affects the musculoskeletal and peripheral nervous systems of surgical patients, typically peaking within the initial hours to days post-procedure

It affects the musculoskeletal and peripheral nervous systems of surgical patients, typically peaking within the initial hours to days post-procedure

Pathophysiologically, the pain stems from extensive tissue trauma, including bone resection, periosteal disruption, capsular distension, and soft-tissue injury, which incite local inflammation, peripheral nociceptor sensitization, and heightened central nervous system responsiveness Clinically characterized by localized arthralgia, hyperalgesia, muscle spasm, and mechanical sensitivity upon joint flexion, this acute state can significantly restrict early mobilization and joint rehabilitation if ...