Adenosine deaminase severe combined immune deficiency

Adenosine deaminase severe combined immune deficiency is an autosomal recessive inborn error of metabolism and primary immunodeficiency caused by mutations in the *ADA* gene This leads to profound, combined T-, B-, and natural killer-cell lymphopenia and secondary systemic abnormalities

Adenosine deaminase severe combined immune deficiency is an autosomal recessive inborn error of metabolism and primary immunodeficiency caused by mutations in the *ADA* gene

Adenosine deaminase severe combined immune deficiency is an autosomal recessive inborn error of metabolism and primary immunodeficiency caused by mutations in the *ADA* gene

The deficiency of the adenosine deaminase enzyme causes intracellular accumulation of toxic purine metabolites, primarily deoxyadenosine and deoxyadenosine triphosphate, which trigger premature apoptosis of rapidly dividing lymphocytes

The deficiency of the adenosine deaminase enzyme causes intracellular accumulation of toxic purine metabolites, primarily deoxyadenosine and deoxyadenosine triphosphate, which trigger premature apoptosis of rapidly dividing lymphocytes

The deficiency of the adenosine deaminase enzyme causes intracellular accumulation of toxic purine metabolites, primarily deoxyadenosine and deoxyadenosine triphosphate, which trigger premature apoptosis of rapidly dividing lymphocytes

This leads to profound, combined T-, B-, and natural killer-cell lymphopenia and secondary systemic abnormalities

Primarily affecting infants within the first six months of life, the condition is clinically characterized by severe failure to thrive, persistent diarrhea, and life-threatening, recurrent opportunistic infections

Primarily affecting infants within the first six months of life, the condition is clinically characterized by severe failure to thrive, persistent diarrhea, and life-threatening, recurrent opportunistic infections

Primarily affecting infants within the first six months of life, the condition is clinically characterized by severe failure to thrive, persistent diarrhea, and life-threatening, recurrent opportunistic infections