Indication

Allergic reaction to insect venom

An allergic reaction to insect venom is an abnormal, immunoglobulin E–mediated hypersensitivity response triggered by exposure to toxins and allergenic proteins injected by stinging insects, predominantly members of the order Hymenoptera, such as honeybees, wasps, hornets, yellow jackets, and fire ants. Read more about Allergic reaction to insect venom

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About Allergic reaction to insect venom.

An allergic reaction to insect venom is an abnormal, immunoglobulin E–mediated hypersensitivity response triggered by exposure to toxins and allergenic proteins injected by stinging insects, predominantly members of the order Hymenoptera, such as honeybees, wasps, hornets, yellow jackets, and fire ants.

The condition can affect pediatric and adult populations, with clinical manifestations ranging from exaggerated, extensive cutaneous swelling at the sting site to multi-organ, life-threatening systemic involvement.

Pathophysiologically, re-exposure to specific venom antigens in a sensitized individual prompts mast cell and basophil degranulation, causing the rapid release of histamine and other inflammatory mediators.

Clinical features may include diffuse urticaria, angioedema, bronchospasm, laryngeal edema, gastrointestinal distress, and profound cardiovascular collapse or anaphylactic shock.

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