Amyloidosis

Amyloidosis is a heterogeneous group of rare protein-misfolding disorders characterized by the extracellular deposition of insoluble, abnormal protein fibrils in tissues and organs Depending on the specific precursor protein and organ involvement, clinical features frequently include restrictive cardiomyopathy, heart failure, nephrotic syndrome, renal impairment, and sensorimotor or autonomic neuropathies

Amyloidosis is a heterogeneous group of rare protein-misfolding disorders characterized by the extracellular deposition of insoluble, abnormal protein fibrils in tissues and organs It can present as a localized condition or as a progressive systemic disease that most commonly affects the heart, kidneys, peripheral and autonomic nervous systems, gastrointestinal tract, and liver Pathophysiologically, normally soluble precursor proteins aggregate into rigid, beta-sheet fibrils that disrupt normal ...

Amyloidosis is a heterogeneous group of rare protein-misfolding disorders characterized by the extracellular deposition of insoluble, abnormal protein fibrils in tissues and organs Pathophysiologically, normally soluble precursor proteins aggregate into rigid, beta-sheet fibrils that disrupt normal tissue architecture and induce cytotoxicity

It can present as a localized condition or as a progressive systemic disease that most commonly affects the heart, kidneys, peripheral and autonomic nervous systems, gastrointestinal tract, and liver

Depending on the specific precursor protein and organ involvement, clinical features frequently include restrictive cardiomyopathy, heart failure, nephrotic syndrome, renal impairment, and sensorimotor or autonomic neuropathies

Depending on the specific precursor protein and organ involvement, clinical features frequently include restrictive cardiomyopathy, heart failure, nephrotic syndrome, renal impairment, and sensorimotor or autonomic neuropathies