Anticholinergic toxicity

Anticholinergic toxicity is an acute toxic syndrome caused by the competitive antagonism of acetylcholine at central and peripheral muscarinic receptors

Anticholinergic toxicity is an acute toxic syndrome caused by the competitive antagonism of acetylcholine at central and peripheral muscarinic receptors

Anticholinergic toxicity is an acute toxic syndrome caused by the competitive antagonism of acetylcholine at central and peripheral muscarinic receptors

It typically affects the central nervous system and the autonomic nervous system across diverse patient populations, with older adults exhibiting heightened vulnerability due to age-related pharmacokinetic changes and polypharmacy

Clinically, the toxidrome is defined by peripheral signs of parasympathetic blockade—including tachycardia, mydriasis, anhidrosis, hyperthermia, dry mucous membranes, urinary retention, and decreased bowel sounds—accompanied by central manifestations such as confusion, agitation, visual hallucinations, delirium, and potentially seizures or coma

Clinically, the toxidrome is defined by peripheral signs of parasympathetic blockade—including tachycardia, mydriasis, anhidrosis, hyperthermia, dry mucous membranes, urinary retention, and decreased bowel sounds—accompanied by central manifestations such as confusion, agitation, visual hallucinations, delirium, and potentially seizures or coma

Clinically, the toxidrome is defined by peripheral signs of parasympathetic blockade—including tachycardia, mydriasis, anhidrosis, hyperthermia, dry mucous membranes, urinary retention, and decreased bowel sounds—accompanied by central manifestations such as confusion, agitation, visual hallucinations, delirium, and potentially seizures or coma