Indication

Asymptomatic congenita syphilis

Asymptomatic congenital syphilis refers to a subclinical infection in neonates or infants caused by the transplacental transmission of the spirochete bacterium *Treponema pallidum* from an untreated or inadequately treated pregnant individual. Read more about Asymptomatic congenita syphilis

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About Asymptomatic congenita syphilis.

Asymptomatic congenital syphilis refers to a subclinical infection in neonates or infants caused by the transplacental transmission of the spirochete bacterium *Treponema pallidum* from an untreated or inadequately treated pregnant individual.

Although affected infants lack overt clinical signs—such as snuffles, cutaneous lesions, hepatosplenomegaly, or skeletal abnormalities—the spirochete disseminates systemically during fetal life and can silently involve the central nervous system, musculoskeletal structures, and reticuloendothelial system.

The condition is typically identified through maternal serologic screening at delivery alongside infant quantitative nontreponemal antibody testing and risk stratification based on maternal treatment history.

Without prompt recognition and therapy, subclinical congenital infection can progress to late symptomatic disease marked by sensorineural hearing loss, interstitial keratitis, and skeletal deformities.

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