Indication

Breath test for abnormal urease

The phrase "breath test for abnormal urease" describes a noninvasive diagnostic procedure and surrogate laboratory biomarker evaluation rather than a discrete disease state. Read more about Breath test for abnormal urease

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About Breath test for abnormal urease.

The phrase "breath test for abnormal urease" describes a noninvasive diagnostic procedure and surrogate laboratory biomarker evaluation rather than a discrete disease state.

It is used primarily to assess the upper gastrointestinal system—specifically the gastric mucosa in adult and pediatric populations—for active bacterial colonization by *Helicobacter pylori*.

Because mammalian gastric tissue lacks endogenous urease, the presence of abnormal urease activity reflects bacterial production of the enzyme, which hydrolyzes oral isotopically labeled urea into ammonia and labeled carbon dioxide that is subsequently absorbed into the bloodstream and exhaled.

Detecting this labeled exhaled carbon dioxide identifies active infection, assisting in the initial diagnosis of *Helicobacter pylori* or confirming eradication following antimicrobial therapy.

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