Indication
Cholestatic pruritus in patients with Alagille syndrome
Cholestatic pruritus in patients with Alagille syndrome is a severe, chronic itching disorder arising as a major complication of Alagille syndrome, an autosomal dominant genetic condition predominantly affecting the hepatobiliary system. Read more about Cholestatic pruritus in patients with Alagille syndrome
4 drugs 3 manufacturers
Drugs that treat it
Common Cholestatic pruritus in patients with Alagille syndrome therapies.
BYLVAY (odevixibat)
LIVMARLI (maralixibat chloride)
BYLVAY (odevixibat)
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Coming soonCholestatic pruritus in patients with Alagille syndrome is a severe, chronic itching disorder arising as a major complication of Alagille syndrome, an autosomal dominant genetic condition predominantly affecting the hepatobiliary system.
The underlying pathophysiology involves intrahepatic bile duct paucity leading to impaired bile flow and systemic retention of pruritogenic substances, particularly elevated serum bile acids, which stimulate sensory nerves in the skin.
Primarily observed in pediatric populations but also affecting adolescents and adults, this unremitting pruritus frequently leads to substantial secondary morbidity, including sleep deprivation, emotional distress, and skin excoriation or scarring caused by persistent, forceful scratching.
- nih.gov
Cholestatic pruritus in patients with Alagille syndrome is a severe, chronic itching disorder arising as a major complication of Alagille syndrome, an autosomal dominant genetic condition predominantly affecting the hepatobiliary system The underlying pathophysiology involves intrahepatic bile duct paucity leading to impaired bile flow and systemic retention of pruritogenic substances, particularly elevated serum bile acids, which stimulate sensory nerves in the skin Primarily observed in pediat...
- nih.gov
Cholestatic pruritus in patients with Alagille syndrome is a severe, chronic itching disorder arising as a major complication of Alagille syndrome, an autosomal dominant genetic condition predominantly affecting the hepatobiliary system The underlying pathophysiology involves intrahepatic bile duct paucity leading to impaired bile flow and systemic retention of pruritogenic substances, particularly elevated serum bile acids, which stimulate sensory nerves in the skin
- nih.gov
The underlying pathophysiology involves intrahepatic bile duct paucity leading to impaired bile flow and systemic retention of pruritogenic substances, particularly elevated serum bile acids, which stimulate sensory nerves in the skin Primarily observed in pediatric populations but also affecting adolescents and adults, this unremitting pruritus frequently leads to substantial secondary morbidity, including sleep deprivation, emotional distress, and skin excoriation or scarring caused by persist...
- nih.gov
The underlying pathophysiology involves intrahepatic bile duct paucity leading to impaired bile flow and systemic retention of pruritogenic substances, particularly elevated serum bile acids, which stimulate sensory nerves in the skin
- pharmacytimes.com
Primarily observed in pediatric populations but also affecting adolescents and adults, this unremitting pruritus frequently leads to substantial secondary morbidity, including sleep deprivation, emotional distress, and skin excoriation or scarring caused by persistent, forceful scratching
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