Indication

Chronic graft-versus-host disease

Chronic graft-versus-host disease is a serious, multi-organ alloimmune and autoimmune-like complication that occurs following allogeneic hematopoietic cell transplantation. Read more about Chronic graft-versus-host disease

6 drugs 3 manufacturers

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Drugs that treat it

Common Chronic graft-versus-host disease therapies.

Showing 1–6 of 6 drugs

IMBRUVICA (ibrutinib)

ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·CHRONIC LYMPHOCYTIC LEUKEMIA·+5
PHARMACYCLICS,

IMBRUVICA (ibrutinib)

ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·CHRONIC LYMPHOCYTIC LEUKEMIA·+5
PHARMACYCLICS,

NIKTIMVO (axatilimab-csfr)

IMMUNOSUPPRESS., T-CELL FXN INHIBITING MONOCLONAL ANTIBODIES·CHRONIC GRAFT-VERSUS-HOST DISEASE
Incyte Corporation
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About Chronic graft-versus-host disease.

Chronic graft-versus-host disease is a serious, multi-organ alloimmune and autoimmune-like complication that occurs following allogeneic hematopoietic cell transplantation.

The disease arises when donor-derived immunocompetent T and B cells recognize recipient tissues as foreign, initiating dysregulated immune responses, persistent inflammation, and progressive tissue fibrosis.

It frequently involves the skin, oral mucosa, eyes, liver, gastrointestinal tract, musculoskeletal system, and lungs, leading to clinical manifestations such as sclerotic or lichenoid changes, keratoconjunctivitis sicca, joint contractures, and bronchiolitis obliterans.

Chronic graft-versus-host disease remains a leading cause of late non-relapse morbidity and mortality in post-transplant populations.

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