Cyclic neutropenia

Cyclic neutropenia is a rare hematologic disorder characterized by regular, oscillatory fluctuations in neutrophil production, typically manifesting in infancy or early childhood

Cyclic neutropenia is a rare hematologic disorder characterized by regular, oscillatory fluctuations in neutrophil production, typically manifesting in infancy or early childhood It is primarily caused by autosomal dominant or sporadic mutations in the *ELANE* gene, which disrupt granulopoiesis through accelerated apoptosis of myeloid progenitor cells in the bone marrow During these nadir periods, patients are susceptible to recurrent fevers, aphthous stomatitis, gingivitis, pharyngitis, and bac...

Cyclic neutropenia is a rare hematologic disorder characterized by regular, oscillatory fluctuations in neutrophil production, typically manifesting in infancy or early childhood

It is primarily caused by autosomal dominant or sporadic mutations in the *ELANE* gene, which disrupt granulopoiesis through accelerated apoptosis of myeloid progenitor cells in the bone marrow Affected individuals experience severe neutropenia recurring at approximately 21-day intervals and lasting three to five days During these nadir periods, patients are susceptible to recurrent fevers, aphthous stomatitis, gingivitis, pharyngitis, and bacterial skin or respiratory infections, while remainin...

During these nadir periods, patients are susceptible to recurrent fevers, aphthous stomatitis, gingivitis, pharyngitis, and bacterial skin or respiratory infections, while remaining largely asymptomatic between episodes