Cytomegalovirus retinitis

Cytomegalovirus retinitis is a sight-threatening opportunistic viral infection of the retina caused by the reactivation or primary infection of cytomegalovirus, a beta-herpesvirus

Cytomegalovirus retinitis is a sight-threatening opportunistic viral infection of the retina caused by the reactivation or primary infection of cytomegalovirus, a beta-herpesvirus It predominantly affects severely immunocompromised individuals, most notably patients with advanced acquired immunodeficiency syndrome (AIDS), particularly those with CD4+ T-lymphocyte counts below 50 cells/mm³, as well as organ transplant recipients and individuals undergoing profound immunosuppressive chemotherapy

It predominantly affects severely immunocompromised individuals, most notably patients with advanced acquired immunodeficiency syndrome (AIDS), particularly those with CD4+ T-lymphocyte counts below 50 cells/mm³, as well as organ transplant recipients and individuals undergoing profound immunosuppressive chemotherapy Without prompt intervention, this progressive retinal destruction frequently leads to retinal detachment, optic atrophy, and irreversible blindness

Pathophysiologically, the virus infects retinal cells and vascular endothelial cells, producing full-thickness necrotizing retinitis characterized clinically by expanding granular, white-to-yellow retinal infiltrates often accompanied by extensive intraretinal hemorrhages and vasculitis Without prompt intervention, this progressive retinal destruction frequently leads to retinal detachment, optic atrophy, and irreversible blindness

Pathophysiologically, the virus infects retinal cells and vascular endothelial cells, producing full-thickness necrotizing retinitis characterized clinically by expanding granular, white-to-yellow retinal infiltrates often accompanied by extensive intraretinal hemorrhages and vasculitis