Decreased corneal sensitivity

Decreased corneal sensitivity is an ophthalmic physical sign and clinical state characterized by a partial or complete reduction in the sensory innervation and tactile responsiveness of the cornea Primarily affecting the sensory pathway of the ophthalmic branch of the trigeminal nerve, it commonly occurs in patients with neurotrophic keratitis, diabetic peripheral neuropathy, previous ocular surgery, chronic contact lens wear, or history of herpes viral infections Pathophysiologically, the loss ...

Decreased corneal sensitivity is an ophthalmic physical sign and clinical state characterized by a partial or complete reduction in the sensory innervation and tactile responsiveness of the cornea

Primarily affecting the sensory pathway of the ophthalmic branch of the trigeminal nerve, it commonly occurs in patients with neurotrophic keratitis, diabetic peripheral neuropathy, previous ocular surgery, chronic contact lens wear, or history of herpes viral infections

Pathophysiologically, the loss of sensory nerve signaling impairs protective blink reflexes, decreases basal tear production, and reduces the delivery of essential neurotrophic factors This lack of trophic support leads to corneal epithelial breakdown, delayed wound healing, and an increased risk of persistent epithelial defects, stromal melting, and corneal perforation