Delay or failure of allogenic bone marrow transplant

Delay or failure of allogeneic bone marrow transplant is a life-threatening hematologic complication in patients who undergo allogeneic bone marrow or hematopoietic stem cell transplantation It encompasses both primary graft failure, characterized by the prolonged absence of donor stem cell engraftment and sustained severe pancytopenia by day 28 to 42 post-transplant, and secondary graft failure, marked by a subsequent loss of donor hematopoiesis after initial successful engraftment Pathophysiol...

Delay or failure of allogeneic bone marrow transplant is a life-threatening hematologic complication in patients who undergo allogeneic bone marrow or hematopoietic stem cell transplantation

It encompasses both primary graft failure, characterized by the prolonged absence of donor stem cell engraftment and sustained severe pancytopenia by day 28 to 42 post-transplant, and secondary graft failure, marked by a subsequent loss of donor hematopoiesis after initial successful engraftment Pathophysiologically, this clinical state is driven by immune-mediated host rejection, insufficient donor cell dose, poor graft function, or adverse microenvironmental factors such as opportunistic viral...