Dermatomyositis

Dermatomyositis is a rare, immune-mediated inflammatory myopathy characterized by systemic involvement primarily affecting the striated skeletal muscles and the skin

Dermatomyositis is a rare, immune-mediated inflammatory myopathy characterized by systemic involvement primarily affecting the striated skeletal muscles and the skin It presents across both pediatric and adult populations, clinically marked by progressive, symmetric proximal muscle weakness alongside distinct cutaneous eruptions such as a violaceous heliotrope rash and Gottron papules

It presents across both pediatric and adult populations, clinically marked by progressive, symmetric proximal muscle weakness alongside distinct cutaneous eruptions such as a violaceous heliotrope rash and Gottron papules Pathophysiologically driven by immune complex deposition, microvascular endothelial injury, and type I interferon pathway activation, the disease can also involve extra-muscular systems, frequently causing interstitial lung disease, esophageal dysmotility, and cardiac complicat...

It presents across both pediatric and adult populations, clinically marked by progressive, symmetric proximal muscle weakness alongside distinct cutaneous eruptions such as a violaceous heliotrope rash and Gottron papules

Pathophysiologically driven by immune complex deposition, microvascular endothelial injury, and type I interferon pathway activation, the disease can also involve extra-muscular systems, frequently causing interstitial lung disease, esophageal dysmotility, and cardiac complications, and it carries an elevated association with underlying malignancies in adults