Digitalis toxicity by EKG

Digitalis toxicity by EKG is an electrophysiologic manifestation of cardiac glycoside overdose or accumulation, characterized by diagnostic electrocardiographic abnormalities affecting the cardiovascular conduction system

Digitalis toxicity by EKG is an electrophysiologic manifestation of cardiac glycoside overdose or accumulation, characterized by diagnostic electrocardiographic abnormalities affecting the cardiovascular conduction system In patients taking digitalis agents such as digoxin—particularly older adults or individuals with renal impairment—inhibition of the myocardial sodium-potassium ATPase pump leads to intracellular calcium overload and heightened vagal tone Pathophysiologically, this combined eff...

In patients taking digitalis agents such as digoxin—particularly older adults or individuals with renal impairment—inhibition of the myocardial sodium-potassium ATPase pump leads to intracellular calcium overload and heightened vagal tone

While non-toxic exposure commonly produces the benign "digoxin effect" of downsloping ST-segment depression, true toxicity manifests on an EKG as clinically significant dysrhythmias, including frequent premature ventricular contractions, varying degrees of sinoatrial or atrioventricular nodal block, regularized atrial fibrillation with junctional escape, and characteristically bidirectional ventricular tachycardia

While non-toxic exposure commonly produces the benign "digoxin effect" of downsloping ST-segment depression, true toxicity manifests on an EKG as clinically significant dysrhythmias, including frequent premature ventricular contractions, varying degrees of sinoatrial or atrioventricular nodal block, regularized atrial fibrillation with junctional escape, and characteristically bidirectional ventricular tachycardia