Disseminated aspergillosis

Disseminated aspergillosis is a severe, life-threatening form of invasive fungal disease caused by *Aspergillus* species, most frequently *Aspergillus fumigatus* It primarily occurs in severely immunocompromised hosts, such as patients with prolonged neutropenia, hematologic malignancies, or hematopoietic stem cell and solid organ transplants, as well as those receiving intensive immunosuppressive therapy Pathophysiologically, fungal hyphae exhibit angioinvasion from a primary site—typically the...

Disseminated aspergillosis is a severe, life-threatening form of invasive fungal disease caused by *Aspergillus* species, most frequently *Aspergillus fumigatus* Pathophysiologically, fungal hyphae exhibit angioinvasion from a primary site—typically the lungs or paranasal sinuses—resulting in vascular thrombosis, tissue infarction, and hematogenous seeding across two or more noncontiguous organ systems Clinically, it manifests as refractory fever and rapid multiorgan decline, commonly involving ...

It primarily occurs in severely immunocompromised hosts, such as patients with prolonged neutropenia, hematologic malignancies, or hematopoietic stem cell and solid organ transplants, as well as those receiving intensive immunosuppressive therapy Clinically, it manifests as refractory fever and rapid multiorgan decline, commonly involving metastatic foci in the central nervous system, skin, kidneys, liver, and bones