Indication

Ectopic ACTH syndrome

Ectopic ACTH syndrome is an ACTH-dependent form of Cushing syndrome caused by the autonomous, non-pituitary secretion of adrenocorticotropic hormone from extrapituitary neoplasms. Read more about Ectopic ACTH syndrome

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ACTHREL (corticorelin ovine triflutate)

ECTOPIC ACTH SYNDROME·+1

FERRING PH INC

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About Ectopic ACTH syndrome.

Ectopic ACTH syndrome is an ACTH-dependent form of Cushing syndrome caused by the autonomous, non-pituitary secretion of adrenocorticotropic hormone from extrapituitary neoplasms.

It predominantly affects adults with underlying neuroendocrine tumors or malignancies, most frequently small cell lung carcinomas, bronchial carcinoids, thymic neoplasms, and pancreatic neuroendocrine tumors.

The aberrant ACTH secretion drives bilateral adrenal cortical hyperplasia and uncontrolled, severe hypercortisolemia.

Clinically, it often presents with an acute or aggressive onset characterized by severe metabolic derangements—notably profound hypokalemia, metabolic alkalosis, marked hypertension, muscle wasting, and hyperglycemia—which may precede or overshadow classic cushingoid fat redistribution.

medlineplus.gov
Ectopic ACTH syndrome is an ACTH-dependent form of Cushing syndrome caused by the autonomous, non-pituitary secretion of adrenocorticotropic hormone from extrapituitary neoplasms
mdpi.com
Ectopic ACTH syndrome is an ACTH-dependent form of Cushing syndrome caused by the autonomous, non-pituitary secretion of adrenocorticotropic hormone from extrapituitary neoplasms It predominantly affects adults with underlying neuroendocrine tumors or malignancies, most frequently small cell lung carcinomas, bronchial carcinoids, thymic neoplasms, and pancreatic neuroendocrine tumors Clinically, it often presents with an acute or aggressive onset characterized by severe metabolic derangements—no...
nih.gov
Ectopic ACTH syndrome is an ACTH-dependent form of Cushing syndrome caused by the autonomous, non-pituitary secretion of adrenocorticotropic hormone from extrapituitary neoplasms It predominantly affects adults with underlying neuroendocrine tumors or malignancies, most frequently small cell lung carcinomas, bronchial carcinoids, thymic neoplasms, and pancreatic neuroendocrine tumors The aberrant ACTH secretion drives bilateral adrenal cortical hyperplasia and uncontrolled, severe hypercortisole...
uclahealth.org
It predominantly affects adults with underlying neuroendocrine tumors or malignancies, most frequently small cell lung carcinomas, bronchial carcinoids, thymic neoplasms, and pancreatic neuroendocrine tumors Clinically, it often presents with an acute or aggressive onset characterized by severe metabolic derangements—notably profound hypokalemia, metabolic alkalosis, marked hypertension, muscle wasting, and hyperglycemia—which may precede or overshadow classic cushingoid fat redistribution
nih.gov
The aberrant ACTH secretion drives bilateral adrenal cortical hyperplasia and uncontrolled, severe hypercortisolemia Clinically, it often presents with an acute or aggressive onset characterized by severe metabolic derangements—notably profound hypokalemia, metabolic alkalosis, marked hypertension, muscle wasting, and hyperglycemia—which may precede or overshadow classic cushingoid fat redistribution

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