EGFR-negative, ALK-negative, ROS1-negative non-small cell lung cancer

EGFR-negative, ALK-negative, ROS1-negative non-small cell lung cancer refers to epithelial malignancies of the respiratory system—predominantly adenocarcinomas and large cell or squamous carcinomas—that lack activating mutations in the epidermal growth factor receptor gene, as well as genomic rearrangements in anaplastic lymphoma kinase and ROS proto-oncogene 1 receptor tyrosine kinase

EGFR-negative, ALK-negative, ROS1-negative non-small cell lung cancer refers to epithelial malignancies of the respiratory system—predominantly adenocarcinomas and large cell or squamous carcinomas—that lack activating mutations in the epidermal growth factor receptor gene, as well as genomic rearrangements in anaplastic lymphoma kinase and ROS proto-oncogene 1 receptor tyrosine kinase Tumors in this molecularly defined subset do not harbor these specific oncogenic driver alterations, rendering ...

Affecting the respiratory tract, this clinical state represents a standard stratification category in which systemic management typically pivots toward immune checkpoint inhibitors, platinum-based chemotherapy, or investigation of alternative targetable biomarkers

Affecting the respiratory tract, this clinical state represents a standard stratification category in which systemic management typically pivots toward immune checkpoint inhibitors, platinum-based chemotherapy, or investigation of alternative targetable biomarkers