EGFR T790M mutation-positive non-small cell lung cancer

EGFR T790M mutation-positive non-small cell lung cancer is a molecularly defined subtype of epithelial lung malignancy characterized by a specific threonine-to-methionine substitution at amino acid position 790 within exon 20 of the epidermal growth factor receptor gene This alteration primarily emerges in patients with advanced or metastatic non-small cell lung cancer as an acquired mechanism of secondary resistance following prior therapy with first- or second-generation EGFR tyrosine kinase i...

EGFR T790M mutation-positive non-small cell lung cancer is a molecularly defined subtype of epithelial lung malignancy characterized by a specific threonine-to-methionine substitution at amino acid position 790 within exon 20 of the epidermal growth factor receptor gene

This alteration primarily emerges in patients with advanced or metastatic non-small cell lung cancer as an acquired mechanism of secondary resistance following prior therapy with first- or second-generation EGFR tyrosine kinase inhibitors, though it rarely arises de novo

This alteration primarily emerges in patients with advanced or metastatic non-small cell lung cancer as an acquired mechanism of secondary resistance following prior therapy with first- or second-generation EGFR tyrosine kinase inhibitors, though it rarely arises de novo

Pathophysiologically, the mutation alters the ATP-binding pocket of the kinase domain via steric hindrance and increased affinity for ATP, restoring downstream oncogenic signaling and promoting tumor progression