Eosinophilic asthma

Eosinophilic asthma is a distinct clinical phenotype of asthma characterized by prominent type 2 airway inflammation and the pathologic accumulation of eosinophils within the respiratory tract and peripheral circulation

Eosinophilic asthma is a distinct clinical phenotype of asthma characterized by prominent type 2 airway inflammation and the pathologic accumulation of eosinophils within the respiratory tract and peripheral circulation

Primarily affecting the lower respiratory system in both pediatric and adult populations—frequently presenting as severe, late-onset, or corticosteroid-refractory disease—it commonly coexists with upper airway conditions such as chronic rhinosinusitis and nasal polyposis Pathophysiologically, cytokine signaling (notably via interleukin-5, interleukin-4, and interleukin-13) drives eosinophil maturation, recruitment, and degranulation

Primarily affecting the lower respiratory system in both pediatric and adult populations—frequently presenting as severe, late-onset, or corticosteroid-refractory disease—it commonly coexists with upper airway conditions such as chronic rhinosinusitis and nasal polyposis

Pathophysiologically, cytokine signaling (notably via interleukin-5, interleukin-4, and interleukin-13) drives eosinophil maturation, recruitment, and degranulation This process releases cytotoxic granule proteins and inflammatory mediators that provoke bronchial hyperresponsiveness, recurrent airflow obstruction, mucus plugging, and progressive tissue remodeling

This process releases cytotoxic granule proteins and inflammatory mediators that provoke bronchial hyperresponsiveness, recurrent airflow obstruction, mucus plugging, and progressive tissue remodeling