Ethylene glycol toxicity

Ethylene glycol toxicity is an acute, potentially life-threatening toxicological emergency caused by the ingestion of ethylene glycol, a common constituent of automotive antifreeze and industrial solvents While the parent compound initially causes central nervous system depression resembling ethanol intoxication, systemic toxicity is primarily mediated by its organic acid metabolites, including glycolic acid, glyoxylic acid, and oxalic acid Hallmark features include an elevated osmolal gap, calc...

Ethylene glycol toxicity is an acute, potentially life-threatening toxicological emergency caused by the ingestion of ethylene glycol, a common constituent of automotive antifreeze and industrial solvents

While the parent compound initially causes central nervous system depression resembling ethanol intoxication, systemic toxicity is primarily mediated by its organic acid metabolites, including glycolic acid, glyoxylic acid, and oxalic acid

While the parent compound initially causes central nervous system depression resembling ethanol intoxication, systemic toxicity is primarily mediated by its organic acid metabolites, including glycolic acid, glyoxylic acid, and oxalic acid These metabolites produce severe high anion gap metabolic acidosis, cardiopulmonary compromise, and acute kidney injury Hallmark features include an elevated osmolal gap, calcium oxalate crystalluria, hypocalcemia secondary to oxalate chelation, and acute tubu...

These metabolites produce severe high anion gap metabolic acidosis, cardiopulmonary compromise, and acute kidney injury

These metabolites produce severe high anion gap metabolic acidosis, cardiopulmonary compromise, and acute kidney injury Hallmark features include an elevated osmolal gap, calcium oxalate crystalluria, hypocalcemia secondary to oxalate chelation, and acute tubular necrosis that may culminate in renal failure or death if left untreated