CABOMETYX (cabozantinib s-malate)
ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·RENAL CELL CARCINOMA·+4
EXELIXIS, INC.
Indication
Extra-pancreatic neuroendocrine tumor
An extra-pancreatic neuroendocrine tumor is a heterogeneous neoplasm arising from neuroendocrine cells situated outside the pancreas, most frequently within the gastrointestinal tract (such as the small intestine, appendix, stomach, or rectum) and the bronchopulmonary system. Read more about Extra-pancreatic neuroendocrine tumor
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Coming soonAn extra-pancreatic neuroendocrine tumor is a heterogeneous neoplasm arising from neuroendocrine cells situated outside the pancreas, most frequently within the gastrointestinal tract (such as the small intestine, appendix, stomach, or rectum) and the bronchopulmonary system.
Affecting adults across various demographics, these tumors originate from the diffuse endocrine system and are characterized by neurosecretory granules expressing markers such as synaptophysin and chromogranin A.
Pathophysiologically, they may be nonfunctioning or functioning; functioning subtypes secrete excess bioactive amines and peptides (notably serotonin), which can precipitate paraneoplastic conditions like carcinoid syndrome.
Clinically, these tumors range from slow-growing, well-differentiated lesions to aggressive, poorly differentiated carcinomas that frequently present with mass effect, abdominal discomfort, bowel obstruction, flushing, diarrhea, or metastatic disease, commonly to the liver.
- nih.gov
An extra-pancreatic neuroendocrine tumor is a heterogeneous neoplasm arising from neuroendocrine cells situated outside the pancreas, most frequently within the gastrointestinal tract (such as the small intestine, appendix, stomach, or rectum) and the bronchopulmonary system
- nih.gov
An extra-pancreatic neuroendocrine tumor is a heterogeneous neoplasm arising from neuroendocrine cells situated outside the pancreas, most frequently within the gastrointestinal tract (such as the small intestine, appendix, stomach, or rectum) and the bronchopulmonary system Affecting adults across various demographics, these tumors originate from the diffuse endocrine system and are characterized by neurosecretory granules expressing markers such as synaptophysin and chromogranin A. Pathophysio...
- nih.gov
Affecting adults across various demographics, these tumors originate from the diffuse endocrine system and are characterized by neurosecretory granules expressing markers such as synaptophysin and chromogranin A Affecting adults across various demographics, these tumors originate from the diffuse endocrine system and are characterized by neurosecretory granules expressing markers such as synaptophysin and chromogranin A. Pathophysiologically, they may be nonfunctioning or functioning; functionin...
- cancer.gov
Affecting adults across various demographics, these tumors originate from the diffuse endocrine system and are characterized by neurosecretory granules expressing markers such as synaptophysin and chromogranin A
- nih.gov
Clinically, these tumors range from slow-growing, well-differentiated lesions to aggressive, poorly differentiated carcinomas that frequently present with mass effect, abdominal discomfort, bowel obstruction, flushing, diarrhea, or metastatic disease, commonly to the liver
- nih.gov
Clinically, these tumors range from slow-growing, well-differentiated lesions to aggressive, poorly differentiated carcinomas that frequently present with mass effect, abdominal discomfort, bowel obstruction, flushing, diarrhea, or metastatic disease, commonly to the liver
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