Fungal sepsis

Fungal sepsis is a life-threatening clinical syndrome defined by acute, life-threatening organ dysfunction resulting from a dysregulated host immune response to an invasive fungal infection Pathophysiologically, the translocation or hematogenous dissemination of fungal pathogens provokes widespread endothelial activation, systemic inflammation, impaired microvascular perfusion, and metabolic derangements, which manifest clinically as hemodynamic instability, fever or hypothermia, tachypnea, alte...

Fungal sepsis is a life-threatening clinical syndrome defined by acute, life-threatening organ dysfunction resulting from a dysregulated host immune response to an invasive fungal infection Pathophysiologically, the translocation or hematogenous dissemination of fungal pathogens provokes widespread endothelial activation, systemic inflammation, impaired microvascular perfusion, and metabolic derangements, which manifest clinically as hemodynamic instability, fever or hypothermia, tachypnea, alte...

It most frequently arises from fungemia or deep-seated tissue invasion caused by opportunistic organisms such as *Candida* species—and less commonly *Aspergillus*, *Cryptococcus*, or endemic mycoses—frequently affecting critically ill, hospitalized, or immunocompromised populations, including patients with prolonged central venous catheterization, broad-spectrum antibiotic exposure, neutropenia, or recent major surgery

It most frequently arises from fungemia or deep-seated tissue invasion caused by opportunistic organisms such as *Candida* species—and less commonly *Aspergillus*, *Cryptococcus*, or endemic mycoses—frequently affecting critically ill, hospitalized, or immunocompromised populations, including patients with prolonged central venous catheterization, broad-spectrum antibiotic exposure, neutropenia, or recent major surgery

It most frequently arises from fungemia or deep-seated tissue invasion caused by opportunistic organisms such as *Candida* species—and less commonly *Aspergillus*, *Cryptococcus*, or endemic mycoses—frequently affecting critically ill, hospitalized, or immunocompromised populations, including patients with prolonged central venous catheterization, broad-spectrum antibiotic exposure, neutropenia, or recent major surgery

It most frequently arises from fungemia or deep-seated tissue invasion caused by opportunistic organisms such as *Candida* species—and less commonly *Aspergillus*, *Cryptococcus*, or endemic mycoses—frequently affecting critically ill, hospitalized, or immunocompromised populations, including patients with prolonged central venous catheterization, broad-spectrum antibiotic exposure, neutropenia, or recent major surgery

Pathophysiologically, the translocation or hematogenous dissemination of fungal pathogens provokes widespread endothelial activation, systemic inflammation, impaired microvascular perfusion, and metabolic derangements, which manifest clinically as hemodynamic instability, fever or hypothermia, tachypnea, altered mental status, and progressive multi-organ failure

Pathophysiologically, the translocation or hematogenous dissemination of fungal pathogens provokes widespread endothelial activation, systemic inflammation, impaired microvascular perfusion, and metabolic derangements, which manifest clinically as hemodynamic instability, fever or hypothermia, tachypnea, altered mental status, and progressive multi-organ failure