Generalized vaccinia

Generalized vaccinia is an uncommon systemic complication of smallpox vaccination characterized by widespread cutaneous dissemination of the live vaccinia virus, most frequently occurring in primary vaccine recipients Clinically, it manifests six to nine days post-vaccination as a generalized maculopapular, vesicular, or pustular rash on normal skin, often accompanied by systemic symptoms such as fever, malaise, and headache While generalized vaccinia is typically benign and self-limiting in imm...

Generalized vaccinia is an uncommon systemic complication of smallpox vaccination characterized by widespread cutaneous dissemination of the live vaccinia virus, most frequently occurring in primary vaccine recipients Clinically, it manifests six to nine days post-vaccination as a generalized maculopapular, vesicular, or pustular rash on normal skin, often accompanied by systemic symptoms such as fever, malaise, and headache While generalized vaccinia is typically benign and self-limiting in imm...

Pathophysiologically, the condition results from transient hematogenous dissemination (viremia) from the primary inoculation site rather than accidental autoinoculation

Pathophysiologically, the condition results from transient hematogenous dissemination (viremia) from the primary inoculation site rather than accidental autoinoculation

Clinically, it manifests six to nine days post-vaccination as a generalized maculopapular, vesicular, or pustular rash on normal skin, often accompanied by systemic symptoms such as fever, malaise, and headache