Graft-versus-host disease

Graft-versus-host disease is a systemic alloimmune complication occurring primarily after allogeneic hematopoietic stem cell transplantation, in which immunocompetent donor T lymphocytes recognize host histocompatibility antigens as foreign and mount an immune attack against recipient tissues

Graft-versus-host disease is a systemic alloimmune complication occurring primarily after allogeneic hematopoietic stem cell transplantation, in which immunocompetent donor T lymphocytes recognize host histocompatibility antigens as foreign and mount an immune attack against recipient tissues

The condition is broadly classified into acute and chronic forms based on clinical presentation and timing Acute manifestations characteristically involve maculopapular rash, secretory diarrhea, and cholestatic hepatitis, whereas chronic disease features widespread autoimmune-like inflammation and progressive tissue fibrosis affecting the skin, mouth, eyes, liver, lungs, and musculoskeletal system

The condition is broadly classified into acute and chronic forms based on clinical presentation and timing

Acute manifestations characteristically involve maculopapular rash, secretory diarrhea, and cholestatic hepatitis, whereas chronic disease features widespread autoimmune-like inflammation and progressive tissue fibrosis affecting the skin, mouth, eyes, liver, lungs, and musculoskeletal system

Acute manifestations characteristically involve maculopapular rash, secretory diarrhea, and cholestatic hepatitis, whereas chronic disease features widespread autoimmune-like inflammation and progressive tissue fibrosis affecting the skin, mouth, eyes, liver, lungs, and musculoskeletal system