Growth failure due to Prader-Willi syndrome

Growth failure due to Prader-Willi syndrome is a pediatric endocrine and neurodevelopmental manifestation marked by subnormal linear growth velocity and diminished final adult height Occurring in children with Prader-Willi syndrome—a rare genetic condition caused by the loss of paternally expressed genes in the chromosome 15q11–q13 region—this growth deficit is primarily driven by hypothalamic dysfunction leading to impaired growth hormone secretion and low circulating insulin-like growth factor...

Growth failure due to Prader-Willi syndrome is a pediatric endocrine and neurodevelopmental manifestation marked by subnormal linear growth velocity and diminished final adult height

Occurring in children with Prader-Willi syndrome—a rare genetic condition caused by the loss of paternally expressed genes in the chromosome 15q11–q13 region—this growth deficit is primarily driven by hypothalamic dysfunction leading to impaired growth hormone secretion and low circulating insulin-like growth factor 1 (IGF-1) levels

Clinically, affected pediatric patients present with marked short stature, delayed bone age, neonatal muscular hypotonia, and altered body composition characterized by reduced lean muscle mass and increased adiposity

Clinically, affected pediatric patients present with marked short stature, delayed bone age, neonatal muscular hypotonia, and altered body composition characterized by reduced lean muscle mass and increased adiposity