Growth failure in child with short stature homeobox-containing gene (SHOX) deficiency

Growth failure in a child with short stature homeobox-containing gene (SHOX) deficiency is a pediatric skeletal growth disorder caused by haploinsufficiency of the *SHOX* gene located on the pseudoautosomal region of the sex chromosomes Affected children present with subnormal linear height velocity and significantly reduced adult height potential, which may manifest as isolated short stature or as part of a dyschondrosteosis phenotype characterized by mesomelic limb shortening, muscular hypertr...

Growth failure in a child with short stature homeobox-containing gene (SHOX) deficiency is a pediatric skeletal growth disorder caused by haploinsufficiency of the *SHOX* gene located on the pseudoautosomal region of the sex chromosomes This genetic disruption impairs chondrocyte proliferation and differentiation within the epiphyseal growth plates of long bones Affected children present with subnormal linear height velocity and significantly reduced adult height potential, which may manifest as...