Hepatic veno-occlusive disease

Hepatic veno-occlusive disease, also known as sinusoidal obstruction syndrome, is a potentially life-threatening vascular liver disorder primarily affecting patients exposed to toxic insults, most notably high-dose conditioning chemotherapy or radiation preceding hematopoietic stem cell transplantation Clinically, it is characterized by tender hepatomegaly, rapid fluid retention manifesting as ascites and unexplained weight gain, and hyperbilirubinemia, which can progress to multiorgan dysfuncti...

Hepatic veno-occlusive disease, also known as sinusoidal obstruction syndrome, is a potentially life-threatening vascular liver disorder primarily affecting patients exposed to toxic insults, most notably high-dose conditioning chemotherapy or radiation preceding hematopoietic stem cell transplantation

The condition is triggered by toxic injury to hepatic sinusoidal endothelial cells and centrilobular hepatocytes, leading to nonthrombotic occlusion of terminal hepatic venules, sinusoidal congestion, and impaired intrahepatic blood flow Clinically, it is characterized by tender hepatomegaly, rapid fluid retention manifesting as ascites and unexplained weight gain, and hyperbilirubinemia, which can progress to multiorgan dysfunction in severe cases

The condition is triggered by toxic injury to hepatic sinusoidal endothelial cells and centrilobular hepatocytes, leading to nonthrombotic occlusion of terminal hepatic venules, sinusoidal congestion, and impaired intrahepatic blood flow

The condition is triggered by toxic injury to hepatic sinusoidal endothelial cells and centrilobular hepatocytes, leading to nonthrombotic occlusion of terminal hepatic venules, sinusoidal congestion, and impaired intrahepatic blood flow