Indication

Hepatorenal syndrome

Hepatorenal syndrome is a life-threatening form of functional renal failure that develops as a complication in patients with advanced liver disease, decompensated cirrhosis with ascites, or acute liver failure. Read more about Hepatorenal syndrome

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About Hepatorenal syndrome.

Hepatorenal syndrome is a life-threatening form of functional renal failure that develops as a complication in patients with advanced liver disease, decompensated cirrhosis with ascites, or acute liver failure.

The condition primarily impacts the renal and cardiovascular systems in the setting of severe portal hypertension.

Pathophysiologically, portal hypertension induces splanchnic arterial vasodilation, resulting in reduced effective circulating arterial blood volume.

This triggers marked compensatory activation of endogenous vasoconstrictor pathways—including the renin-angiotensin-aldosterone and sympathetic nervous systems—causing profound renal vasoconstriction, severely reduced renal blood flow, and a rapid decline in glomerular filtration rate despite structurally intact kidneys.

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