High-risk neuroblastoma

High-risk neuroblastoma is an aggressive clinical subset of neuroblastoma, an extracranial solid tumor of primitive neural crest cells that typically arises in the adrenal medulla or sympathetic ganglia Its defining pathophysiologic hallmarks include unfavorable tumor histopathology and distinct cytogenetic abnormalities, most notably *MYCN* oncogene amplification and recurrent segmental chromosomal alterations, which drive rapid disease progression, treatment resistance, and high rates of recur...

High-risk neuroblastoma is an aggressive clinical subset of neuroblastoma, an extracranial solid tumor of primitive neural crest cells that typically arises in the adrenal medulla or sympathetic ganglia Primarily affecting infants and young children, this categorization encompasses patients with metastatic dissemination diagnosed at or after 18 months of age, or localized disease characterized by high-risk biological features regardless of age

Its defining pathophysiologic hallmarks include unfavorable tumor histopathology and distinct cytogenetic abnormalities, most notably *MYCN* oncogene amplification and recurrent segmental chromosomal alterations, which drive rapid disease progression, treatment resistance, and high rates of recurrence