Hypofibrinogenemia

Hypofibrinogenemia is a quantitative coagulation disorder characterized by abnormally low circulating levels of fibrinogen (factor I), typically defined as a plasma concentration below 1.5 g/L It affects the hematologic and vascular systems and can occur as a rare congenital bleeding disorder—most often inherited in an autosomal dominant manner due to heterozygous mutations in the *FGA*, *FGB*, or *FGG* genes—or as an acquired state secondary to severe trauma, hemodilution, hepatic dysfunction, ...

Hypofibrinogenemia is a quantitative coagulation disorder characterized by abnormally low circulating levels of fibrinogen (factor I), typically defined as a plasma concentration below 1.5 g/L

It affects the hematologic and vascular systems and can occur as a rare congenital bleeding disorder—most often inherited in an autosomal dominant manner due to heterozygous mutations in the *FGA*, *FGB*, or *FGG* genes—or as an acquired state secondary to severe trauma, hemodilution, hepatic dysfunction, or consumptive coagulopathies such as disseminated intravascular coagulation Because fibrinogen is essential for platelet aggregation and conversion into a stable fibrin clot, the deficiency im...

It affects the hematologic and vascular systems and can occur as a rare congenital bleeding disorder—most often inherited in an autosomal dominant manner due to heterozygous mutations in the *FGA*, *FGB*, or *FGG* genes—or as an acquired state secondary to severe trauma, hemodilution, hepatic dysfunction, or consumptive coagulopathies such as disseminated intravascular coagulation Because fibrinogen is essential for platelet aggregation and conversion into a stable fibrin clot, the deficiency im...

It affects the hematologic and vascular systems and can occur as a rare congenital bleeding disorder—most often inherited in an autosomal dominant manner due to heterozygous mutations in the *FGA*, *FGB*, or *FGG* genes—or as an acquired state secondary to severe trauma, hemodilution, hepatic dysfunction, or consumptive coagulopathies such as disseminated intravascular coagulation

Because fibrinogen is essential for platelet aggregation and conversion into a stable fibrin clot, the deficiency impairs primary and secondary hemostasis, leading to clinical manifestations that range from an asymptomatic laboratory finding to mild-to-severe mucocutaneous bleeding, prolonged surgical or post-traumatic hemorrhage, and paradoxical thrombosis