IgE-mediated food allergy

IgE-mediated food allergy is an adverse, reproducible type I hypersensitivity reaction driven by allergen-specific immunoglobulin E antibodies directed against dietary proteins Pathophysiologically, dietary antigens cross-link specific IgE bound to high-affinity Fc receptors on mast cells and basophils, triggering immediate degranulation and the release of histamine, leukotrienes, and other inflammatory mediators Clinical manifestations range from mild cutaneous, gastrointestinal, or mucosal sym...

IgE-mediated food allergy is an adverse, reproducible type I hypersensitivity reaction driven by allergen-specific immunoglobulin E antibodies directed against dietary proteins

It affects pediatric and adult populations, commonly manifesting within minutes to a few hours following allergen ingestion or contact

Pathophysiologically, dietary antigens cross-link specific IgE bound to high-affinity Fc receptors on mast cells and basophils, triggering immediate degranulation and the release of histamine, leukotrienes, and other inflammatory mediators

Clinical manifestations range from mild cutaneous, gastrointestinal, or mucosal symptoms (such as urticaria, angioedema, pruritus, and emesis) to severe, multi-organ impairment, bronchospasm, cardiovascular collapse, and life-threatening anaphylaxis