Immunoglobulin G4-related disease

Immunoglobulin G4-related disease is a chronic, immune-mediated fibroinflammatory condition characterized by tumefactive lesions, tissue swelling, and progressive organ dysfunction that predominantly affects middle-aged and older adults While it can involve virtually any anatomical site, it frequently affects the pancreas, salivary and lacrimal glands, retroperitoneum, aorta, and kidneys Pathophysiologically, the disease is defined by dense lymphoplasmacytic infiltrates enriched with IgG4-positi...

Immunoglobulin G4-related disease is a chronic, immune-mediated fibroinflammatory condition characterized by tumefactive lesions, tissue swelling, and progressive organ dysfunction that predominantly affects middle-aged and older adults While it can involve virtually any anatomical site, it frequently affects the pancreas, salivary and lacrimal glands, retroperitoneum, aorta, and kidneys Untreated, the resultant fibrosing inflammatory process can mimic malignancy and lead to irreversible structu...

Immunoglobulin G4-related disease is a chronic, immune-mediated fibroinflammatory condition characterized by tumefactive lesions, tissue swelling, and progressive organ dysfunction that predominantly affects middle-aged and older adults

Pathophysiologically, the disease is defined by dense lymphoplasmacytic infiltrates enriched with IgG4-positive plasma cells, storiform fibrosis, obliterative phlebitis, and frequently elevated serum concentrations of immunoglobulin G4

Untreated, the resultant fibrosing inflammatory process can mimic malignancy and lead to irreversible structural injury and end-organ failure

Untreated, the resultant fibrosing inflammatory process can mimic malignancy and lead to irreversible structural injury and end-organ failure