Infant botulism

Infant botulism is a neuroparalytic disease occurring in infants—predominantly those under six months of age—caused by intestinal colonization with *Clostridium botulinum* spores and subsequent in vivo neurotoxin production Clinically, it is characterized by an initial onset of constipation followed by symmetric, descending flaccid paralysis This typically manifests as bulbar palsies, weak cry, poor feeding, diminished suck and gag reflexes, ptosis, generalized hypotonia, and potentially fatal r...

Infant botulism is a neuroparalytic disease occurring in infants—predominantly those under six months of age—caused by intestinal colonization with *Clostridium botulinum* spores and subsequent in vivo neurotoxin production The absorbed botulinum neurotoxin irreversibly inhibits acetylcholine release at peripheral cholinergic synapses and neuromuscular junctions

Infant botulism is a neuroparalytic disease occurring in infants—predominantly those under six months of age—caused by intestinal colonization with *Clostridium botulinum* spores and subsequent in vivo neurotoxin production Clinically, it is characterized by an initial onset of constipation followed by symmetric, descending flaccid paralysis This typically manifests as bulbar palsies, weak cry, poor feeding, diminished suck and gag reflexes, ptosis, generalized hypotonia, and potentially fatal r...

The absorbed botulinum neurotoxin irreversibly inhibits acetylcholine release at peripheral cholinergic synapses and neuromuscular junctions