Leukocyte adhesion deficiency type 1 (LAD-1)

Leukocyte adhesion deficiency type 1 (LAD-1) is a rare, life-threatening autosomal recessive primary immunodeficiency disorder caused by pathogenic variants in the *ITGB2* gene, which encodes the beta-2 integrin subunit CD18 Characterized primarily in pediatric populations, hallmark clinical features include delayed separation of the umbilical cord, severe omphalitis, impaired wound healing, persistent peripheral blood leukocytosis, and recurrent, non-purulent bacterial and fungal infections aff...

Leukocyte adhesion deficiency type 1 (LAD-1) is a rare, life-threatening autosomal recessive primary immunodeficiency disorder caused by pathogenic variants in the *ITGB2* gene, which encodes the beta-2 integrin subunit CD18

Leukocyte adhesion deficiency type 1 (LAD-1) is a rare, life-threatening autosomal recessive primary immunodeficiency disorder caused by pathogenic variants in the *ITGB2* gene, which encodes the beta-2 integrin subunit CD18

This genetic defect disrupts leukocyte adhesion and prevents neutrophils from transmigrating across vascular endothelium into infected or inflamed tissues

This genetic defect disrupts leukocyte adhesion and prevents neutrophils from transmigrating across vascular endothelium into infected or inflamed tissues

Characterized primarily in pediatric populations, hallmark clinical features include delayed separation of the umbilical cord, severe omphalitis, impaired wound healing, persistent peripheral blood leukocytosis, and recurrent, non-purulent bacterial and fungal infections affecting the skin and mucous membranes