Lichen planus

Lichen planus is a chronic, immune-mediated inflammatory disorder affecting the stratified squamous epithelium of the skin, mucous membranes, hair follicles, and nails, most frequently manifesting in middle-aged adults

Lichen planus is a chronic, immune-mediated inflammatory disorder affecting the stratified squamous epithelium of the skin, mucous membranes, hair follicles, and nails, most frequently manifesting in middle-aged adults Pathophysiologically driven by a cytotoxic T-cell-mediated autoimmune reaction targeting basal keratinocytes, it leads to characteristic interface dermatitis and basal vacuolar degeneration Cutaneous involvement is classically distinguished by pruritic, violaceous, polygonal, flat...

Lichen planus is a chronic, immune-mediated inflammatory disorder affecting the stratified squamous epithelium of the skin, mucous membranes, hair follicles, and nails, most frequently manifesting in middle-aged adults Pathophysiologically driven by a cytotoxic T-cell-mediated autoimmune reaction targeting basal keratinocytes, it leads to characteristic interface dermatitis and basal vacuolar degeneration

Cutaneous involvement is classically distinguished by pruritic, violaceous, polygonal, flat-topped papules and plaques often marked by fine white reticular lines known as Wickham striae, whereas mucosal involvement frequently presents with reticular white lesions, painful erosions, or ulcerations

Cutaneous involvement is classically distinguished by pruritic, violaceous, polygonal, flat-topped papules and plaques often marked by fine white reticular lines known as Wickham striae, whereas mucosal involvement frequently presents with reticular white lesions, painful erosions, or ulcerations