Malignant neoplasm of liver

A malignant neoplasm of the liver is a cancerous tumor originating within hepatic tissue, most commonly presenting in adult populations as hepatocellular carcinoma or intrahepatic cholangiocarcinoma Clinical manifestations often emerge at advanced stages and include right upper quadrant abdominal pain, hepatomegaly, unexplained weight loss, ascites, and worsening hepatic decompensation or jaundice

A malignant neoplasm of the liver is a cancerous tumor originating within hepatic tissue, most commonly presenting in adult populations as hepatocellular carcinoma or intrahepatic cholangiocarcinoma Malignant transformation leads to uncontrolled cellular proliferation, architectural disruption of hepatic parenchyma, and potential vascular invasion into the portal or hepatic venous systems

Pathophysiologically, these malignancies typically arise in the setting of chronic hepatic inflammation, injury, and cirrhosis driven by risk factors such as chronic hepatitis B or C infection, alcohol-related liver disease, or metabolic dysfunction-associated steatotic liver disease

Pathophysiologically, these malignancies typically arise in the setting of chronic hepatic inflammation, injury, and cirrhosis driven by risk factors such as chronic hepatitis B or C infection, alcohol-related liver disease, or metabolic dysfunction-associated steatotic liver disease Clinical manifestations often emerge at advanced stages and include right upper quadrant abdominal pain, hepatomegaly, unexplained weight loss, ascites, and worsening hepatic decompensation or jaundice

Malignant transformation leads to uncontrolled cellular proliferation, architectural disruption of hepatic parenchyma, and potential vascular invasion into the portal or hepatic venous systems