Merkel cell carcinoma

Merkel cell carcinoma is a rare, aggressive neuroendocrine malignancy of the skin that arises within the basal layer of the epidermis and the dermis

Merkel cell carcinoma is a rare, aggressive neuroendocrine malignancy of the skin that arises within the basal layer of the epidermis and the dermis It predominantly affects older adults, fair-skinned individuals, and immunocompromised populations, most commonly developing on chronically sun-exposed areas such as the head, neck, and extremities Pathophysiologically, oncogenesis is strongly driven either by integration of the Merkel cell polyomavirus or by extensive ultraviolet radiation–induced ...

It predominantly affects older adults, fair-skinned individuals, and immunocompromised populations, most commonly developing on chronically sun-exposed areas such as the head, neck, and extremities Clinically, it typically presents as a rapidly growing, painless, firm, flesh-colored to violaceous cutaneous or subcutaneous nodule Pathophysiologically, oncogenesis is strongly driven either by integration of the Merkel cell polyomavirus or by extensive ultraviolet radiation–induced somatic DNA dama...

Clinically, it typically presents as a rapidly growing, painless, firm, flesh-colored to violaceous cutaneous or subcutaneous nodule

Pathophysiologically, oncogenesis is strongly driven either by integration of the Merkel cell polyomavirus or by extensive ultraviolet radiation–induced somatic DNA damage, both pathways conferring high rates of local recurrence and early regional or distant metastasis