Metastatic colorectal cancer with BRAF V600E mutation

Metastatic colorectal cancer with BRAF V600E mutation is an advanced gastrointestinal malignancy in which primary epithelial tumors of the colon or rectum have spread to distant anatomical sites, such as the liver, peritoneum, distant lymph nodes, or lungs This clinically distinct molecular subtype, occurring in approximately 8% to 12% of metastatic colorectal cancer cases, is defined by an activating valine-to-glutamic acid substitution at codon 600 of the BRAF kinase This alteration constituti...

Metastatic colorectal cancer with BRAF V600E mutation is an advanced gastrointestinal malignancy in which primary epithelial tumors of the colon or rectum have spread to distant anatomical sites, such as the liver, peritoneum, distant lymph nodes, or lungs Clinically and pathologically, tumors harboring this mutation frequently originate in the right colon, show mucinous or poorly differentiated histology, demonstrate frequent peritoneal dissemination, and exhibit an aggressive clinical course c...

This clinically distinct molecular subtype, occurring in approximately 8% to 12% of metastatic colorectal cancer cases, is defined by an activating valine-to-glutamic acid substitution at codon 600 of the BRAF kinase This alteration constitutively drives downstream MAPK/ERK pathway signaling independent of upstream epidermal growth factor receptor activation

This clinically distinct molecular subtype, occurring in approximately 8% to 12% of metastatic colorectal cancer cases, is defined by an activating valine-to-glutamic acid substitution at codon 600 of the BRAF kinase Clinically and pathologically, tumors harboring this mutation frequently originate in the right colon, show mucinous or poorly differentiated histology, demonstrate frequent peritoneal dissemination, and exhibit an aggressive clinical course characterized by reduced sensitivity to s...