Indication

Methicillin-resistant Staphylococcus aureus nasal colonization

Methicillin-resistant *Staphylococcus aureus* nasal colonization is an asymptomatic clinical state characterized by the presence and multiplication of beta-lactam-resistant *S. Read more about Methicillin-resistant Staphylococcus aureus nasal colonization

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About Methicillin-resistant Staphylococcus aureus nasal colonization.

Methicillin-resistant *Staphylococcus aureus* nasal colonization is an asymptomatic clinical state characterized by the presence and multiplication of beta-lactam-resistant *S.

aureus* strains within the anterior nares without causing local tissue invasion or active infection.

This carrier state affects the upper respiratory mucosa, frequently occurring in hospitalized individuals, surgical patients, residents of long-term care facilities, and certain community populations.

Pathophysiologically, the nasal vestibule acts as the primary ecological reservoir for the bacterium, which harbors the *mecA* or *mecC* genes conferring resistance to methicillin and other penicillinase-resistant beta-lactams.

While harmless in healthy tissue, this colonization significantly elevates the risk of subsequent endogenous invasive infections—such as bacteremia, pneumonia, and surgical site infections—as well as horizontal transmission in healthcare environments.

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