Microsatellite instability-high colorectal cancer

Microsatellite instability-high colorectal cancer is a distinct molecular subtype of malignancy arising in the colon or rectum, affecting the gastrointestinal system This defect impairs the correction of replication errors, leading to length alterations across repetitive DNA sequences known as microsatellites, high tumor mutational burden, and marked immune infiltration

Microsatellite instability-high colorectal cancer is a distinct molecular subtype of malignancy arising in the colon or rectum, affecting the gastrointestinal system It is pathophysiologically characterized by a hypermutable state caused by deficient DNA mismatch repair, resulting from either sporadic epigenetic silencing (commonly via *MLH1* promoter hypermethylation) or germline mutations associated with Lynch syndrome This defect impairs the correction of replication errors, leading to length...

It is pathophysiologically characterized by a hypermutable state caused by deficient DNA mismatch repair, resulting from either sporadic epigenetic silencing (commonly via *MLH1* promoter hypermethylation) or germline mutations associated with Lynch syndrome

It is pathophysiologically characterized by a hypermutable state caused by deficient DNA mismatch repair, resulting from either sporadic epigenetic silencing (commonly via *MLH1* promoter hypermethylation) or germline mutations associated with Lynch syndrome

This defect impairs the correction of replication errors, leading to length alterations across repetitive DNA sequences known as microsatellites, high tumor mutational burden, and marked immune infiltration Clinically, these tumors predominantly arise in the proximal colon, frequently present at an earlier stage, and exhibit unique prognostic and therapeutic profiles, including heightened sensitivity to immune checkpoint inhibition

Clinically, these tumors predominantly arise in the proximal colon, frequently present at an earlier stage, and exhibit unique prognostic and therapeutic profiles, including heightened sensitivity to immune checkpoint inhibition