Mismatch repair proficient endometrial cancer

Mismatch repair proficient endometrial cancer is a molecularly defined subtype of uterine malignancy originating in the endometrium It affects adult females and is characterized pathophysiologically by functional cellular DNA mismatch repair machinery—demonstrated by intact immunohistochemical nuclear expression of the core mismatch repair proteins MLH1, MSH2, MSH6, and PMS2—and an associated microsatellite stable (MSS) or low microsatellite instability (MSI-L) phenotype Because these tumors typ...

It affects adult females and is characterized pathophysiologically by functional cellular DNA mismatch repair machinery—demonstrated by intact immunohistochemical nuclear expression of the core mismatch repair proteins MLH1, MSH2, MSH6, and PMS2—and an associated microsatellite stable (MSS) or low microsatellite instability (MSI-L) phenotype

Because these tumors typically exhibit lower mutation rates, fewer neoantigens, and a less immunogenic microenvironment than mismatch repair deficient variants, mismatch repair proficient status serves as a critical prognostic and predictive biomarker that informs oncologic risk stratification and dictates eligibility for tailored systemic regimens

Because these tumors typically exhibit lower mutation rates, fewer neoantigens, and a less immunogenic microenvironment than mismatch repair deficient variants, mismatch repair proficient status serves as a critical prognostic and predictive biomarker that informs oncologic risk stratification and dictates eligibility for tailored systemic regimens