Morphea

Morphea, also known as localized scleroderma, is a rare chronic autoimmune connective tissue disorder characterized by localized inflammation, excessive collagen deposition, and sclerosis of the skin and underlying tissues Clinically, active lesions present as erythematous or violaceous inflammatory plaques that gradually progress to indurated, ivory-white, or hyperpigmented sclerotic areas with tissue atrophy While it typically spares internal organs and lacks the systemic vasculopathy of syste...

Morphea, also known as localized scleroderma, is a rare chronic autoimmune connective tissue disorder characterized by localized inflammation, excessive collagen deposition, and sclerosis of the skin and underlying tissues

Morphea, also known as localized scleroderma, is a rare chronic autoimmune connective tissue disorder characterized by localized inflammation, excessive collagen deposition, and sclerosis of the skin and underlying tissues Clinically, active lesions present as erythematous or violaceous inflammatory plaques that gradually progress to indurated, ivory-white, or hyperpigmented sclerotic areas with tissue atrophy While it typically spares internal organs and lacks the systemic vasculopathy of syste...

The disease most commonly affects children and middle-aged adults, with a marked predilection for females

The disease most commonly affects children and middle-aged adults, with a marked predilection for females While it typically spares internal organs and lacks the systemic vasculopathy of systemic sclerosis, deeper involvement of subcutaneous fat, fascia, muscle, or bone can lead to joint contractures, limb asymmetry, and functional impairment

Clinically, active lesions present as erythematous or violaceous inflammatory plaques that gradually progress to indurated, ivory-white, or hyperpigmented sclerotic areas with tissue atrophy