Multicentric Castleman's disease

Multicentric Castleman's disease is a rare, life-threatening lymphoproliferative disorder that affects multiple lymph node stations and lymphoid tissues throughout the body

Multicentric Castleman's disease is a rare, life-threatening lymphoproliferative disorder that affects multiple lymph node stations and lymphoid tissues throughout the body

It can manifest across broad adult populations as either idiopathic or associated with human herpesvirus 8 (HHV-8), the latter frequently occurring alongside human immunodeficiency virus (HIV) co-infection

It can manifest across broad adult populations as either idiopathic or associated with human herpesvirus 8 (HHV-8), the latter frequently occurring alongside human immunodeficiency virus (HIV) co-infection

Pathophysiologically, the disease is driven by a hyperinflammatory cytokine storm—predominantly involving interleukin-6 (IL-6)—which leads to characteristic histopathological lymphadenopathy, polyclonal hypergammaglobulinemia, and profound systemic manifestations including fevers, night sweats, cytopenias, hepatosplenomegaly, and progressive multi-organ dysfunction

Pathophysiologically, the disease is driven by a hyperinflammatory cytokine storm—predominantly involving interleukin-6 (IL-6)—which leads to characteristic histopathological lymphadenopathy, polyclonal hypergammaglobulinemia, and profound systemic manifestations including fevers, night sweats, cytopenias, hepatosplenomegaly, and progressive multi-organ dysfunction