Necrobiosis lipoidica diabeticorum

Necrobiosis lipoidica diabeticorum is a rare, chronic granulomatous skin disease classically associated with diabetes mellitus, particularly affecting young-to-middle-aged adults and exhibiting a marked female predominance Pathophysiologically, the condition is driven by microangiopathic changes, granulomatous inflammation, collagen degeneration (necrobiosis), and lipid deposition within the dermis and subcutaneous tissue Due to marked tissue fragility, affected plaques frequently suffer painful...

Necrobiosis lipoidica diabeticorum is a rare, chronic granulomatous skin disease classically associated with diabetes mellitus, particularly affecting young-to-middle-aged adults and exhibiting a marked female predominance It typically presents on the pretibial surfaces of the lower extremities as well-demarcated, yellowish-brown plaques characterized by raised violaceous borders, central epidermal atrophy, and prominent overlying telangiectasias Due to marked tissue fragility, affected plaques ...

Necrobiosis lipoidica diabeticorum is a rare, chronic granulomatous skin disease classically associated with diabetes mellitus, particularly affecting young-to-middle-aged adults and exhibiting a marked female predominance

It typically presents on the pretibial surfaces of the lower extremities as well-demarcated, yellowish-brown plaques characterized by raised violaceous borders, central epidermal atrophy, and prominent overlying telangiectasias

Pathophysiologically, the condition is driven by microangiopathic changes, granulomatous inflammation, collagen degeneration (necrobiosis), and lipid deposition within the dermis and subcutaneous tissue