Indication

Non-Keratinizing Nasopharyngeal Carcinoma

Non-keratinizing nasopharyngeal carcinoma is an epithelial malignancy arising from the mucosal lining of the nasopharynx, predominantly originating in the pharyngeal recess (fossa of Rosenmüller). Read more about Non-Keratinizing Nasopharyngeal Carcinoma

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About Non-Keratinizing Nasopharyngeal Carcinoma.

Non-keratinizing nasopharyngeal carcinoma is an epithelial malignancy arising from the mucosal lining of the nasopharynx, predominantly originating in the pharyngeal recess (fossa of Rosenmüller).

It represents the vast majority of nasopharyngeal carcinoma cases globally and is strongly endemic to East and Southeast Asia as well as parts of North Africa.

Pathophysiologically, it is nearly universally driven by latent Epstein-Barr virus infection and is histologically subclassified into differentiated and undifferentiated variants, the latter historically termed lymphoepithelioma.

Defining clinical features include a high propensity for early regional cervical lymphadenopathy and distant metastasis, paired with pronounced sensitivity to platinum-based chemotherapy and radiation.

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