PD-L1 positive adenocarcinoma of gastroesophageal junction

PD-L1 positive adenocarcinoma of the gastroesophageal junction refers to a malignant glandular neoplasm arising at the anatomic transition zone between the distal esophagus and proximal stomach, characterized by the measurable expression of programmed death-ligand 1

Pathophysiologically, the tumor cells or surrounding tumor-infiltrating immune cells express PD-L1—typically quantified using immunohistochemical scoring systems like the Combined Positive Score—which binds to PD-1 receptors on T cells to inhibit antitumor immune surveillance and facilitate tumor immune evasion

Pathophysiologically, the tumor cells or surrounding tumor-infiltrating immune cells express PD-L1—typically quantified using immunohistochemical scoring systems like the Combined Positive Score—which binds to PD-1 receptors on T cells to inhibit antitumor immune surveillance and facilitate tumor immune evasion