PD-L1 positive adenocarcinoma of stomach

PD-L1 positive adenocarcinoma of the stomach refers to a malignant epithelial neoplasm originating in the glandular mucosa of the gastric wall that demonstrates pathological expression of programmed death-ligand 1 This clinical state occurs in the digestive system, where neoplastic cells or tumor-infiltrating immune cells express PD-L1, typically quantified by immunohistochemistry using a combined positive score Pathophysiologically, the tumor utilizes PD-L1 expression to bind programmed cell de...

PD-L1 positive adenocarcinoma of the stomach refers to a malignant epithelial neoplasm originating in the glandular mucosa of the gastric wall that demonstrates pathological expression of programmed death-ligand 1

This clinical state occurs in the digestive system, where neoplastic cells or tumor-infiltrating immune cells express PD-L1, typically quantified by immunohistochemistry using a combined positive score

Pathophysiologically, the tumor utilizes PD-L1 expression to bind programmed cell death protein 1 on cytotoxic T cells, promoting immune checkpoint evasion and downregulating host antitumor immunity

Clinically, identification of this biomarker subgroup guides immune checkpoint inhibitor therapy in patients presenting with advanced, recurrent, or metastatic gastric cancer