Persistent pulmonary hypertension of the newborn

Persistent pulmonary hypertension of the newborn is a life-threatening cardiopulmonary condition occurring in neonates—predominantly term and near-term infants—characterized by a failure of the normal circulatory transition at birth It is defined by sustained elevation of pulmonary vascular resistance, which restricts pulmonary blood flow and causes extrapulmonary right-to-left shunting of deoxygenated blood through the patent ductus arteriosus and foramen ovale

Persistent pulmonary hypertension of the newborn is a life-threatening cardiopulmonary condition occurring in neonates—predominantly term and near-term infants—characterized by a failure of the normal circulatory transition at birth

It is defined by sustained elevation of pulmonary vascular resistance, which restricts pulmonary blood flow and causes extrapulmonary right-to-left shunting of deoxygenated blood through the patent ductus arteriosus and foramen ovale This persistent elevation results in severe, refractory hypoxemia and respiratory distress shortly after delivery, frequently occurring idiopathically or secondary to meconium aspiration syndrome, respiratory distress syndrome, pneumonia, or pulmonary hypoplasia

This persistent elevation results in severe, refractory hypoxemia and respiratory distress shortly after delivery, frequently occurring idiopathically or secondary to meconium aspiration syndrome, respiratory distress syndrome, pneumonia, or pulmonary hypoplasia