Polycythemia vera

Polycythemia vera is a chronic myeloproliferative neoplasm characterized by the clonal proliferation of bone marrow hematopoietic stem cells, leading primarily to an autonomous overproduction of red blood cells often accompanied by elevated platelets and white blood cells

Polycythemia vera is a chronic myeloproliferative neoplasm characterized by the clonal proliferation of bone marrow hematopoietic stem cells, leading primarily to an autonomous overproduction of red blood cells often accompanied by elevated platelets and white blood cells The resultant increase in red cell mass and blood viscosity substantially elevates the risk of arterial and venous thrombosis, microvascular disturbances, splenomegaly, and progression to myelofibrosis or acute myeloid leukemia

Polycythemia vera is a chronic myeloproliferative neoplasm characterized by the clonal proliferation of bone marrow hematopoietic stem cells, leading primarily to an autonomous overproduction of red blood cells often accompanied by elevated platelets and white blood cells The resultant increase in red cell mass and blood viscosity substantially elevates the risk of arterial and venous thrombosis, microvascular disturbances, splenomegaly, and progression to myelofibrosis or acute myeloid leukemia

It predominantly affects the hematopoietic and vascular systems in older adults, driven in almost all cases by activating mutations in the Janus kinase 2 gene

It predominantly affects the hematopoietic and vascular systems in older adults, driven in almost all cases by activating mutations in the Janus kinase 2 gene

The resultant increase in red cell mass and blood viscosity substantially elevates the risk of arterial and venous thrombosis, microvascular disturbances, splenomegaly, and progression to myelofibrosis or acute myeloid leukemia